Akathisia is a daytime restlessness that leads to an inability to keep the legs still and is often confused with agitation and hyperactivity.  Nevertheless, it is increasingly recognized as an acute side effect of most dopamine receptor blockers (DRBs), with prevalence estimates of 20% to 30% of exposed subjects.  It is less frequent when atypical antipsychotics are used.  Case reports also document akathisia with the use of selective serotonin reuptake inhibitors (SSRI).

 If treatment is necessary, it includes withdrawal of the offending drug or, if this is not feasible, beta-blockers, anticholinergics, and benzodiazepines.