Amyotrophic lateral sclerosis, also called Lou Gehrig Disease, is a nerve disorder marked by degeneration of upper and lower motor neurons.

This disease is usually fatal within 2-3 years.

- In amyotrophic lateral sclerosis, microglia become phagocytic.
- In amyotrophic lateral sclerosis, there is a combo of UMN lesions and LMN lesions with no sensory deficit.