Plakoglobin (gamma-catenin) interacts directly with the intracellular region of cadherins and also binds directly to desmoplakin and plakophilins. Plakophilins participate in the recruitment of proteins to the plasma membrane.

A mutation in the plakoglobin gene leads to Naxos Disease.

Naxos Disease is an arrythmogenic right ventricular cardiomyopathy (ARVC) and is characterized by wooly hair and palmoplantar keratoderma.

Fat cells also replace the cardiocytes.