Mineralization is impaired.

Condition in which bone becomes progressively softened.

This defect is due to a defect in mineralization of bone resulting from reduced Vitamin D

This condition can result from reduced osteoblast activity while osteoclast activity is normal or even related.

Calcium deficiency in adults gives rise to osteomalacia which is characterized by deficient calcification of recently formed bone and partial decalcification of already calcified matrix.
- Prolonged deficiency of vitamin D (with or without low intake) leads, in adults, to bones which contain regions of deformable, uncalcified osteoid.