Erythrocytes depend on glycolysis

ATPs fuel erythrocyte activities and maintains RBC shape.

Mutant enzyme shows altered kinetics.

Inherited autosomal recessive disorder which affects the survival of red blood cells, causing them to break down easily.

Symptoms of PKD include long-term hemolytic anemia, variable degrees of jaundice, splenomegaly, increased incidence of gallstones, increased BPG with no Heinz bodies