- The retrograde axonal transport to the CNS of tetanus toxin – a protease produced by the vegetative spore form of Clostridium tetani bacteria after entering at a wound site – blocks the release of inhibitory mediators at spinal synapses.
- Spasm contracttion of the jaw muscles (known as trismus), exaggerated reflexes, and respiratory failure are characteristic clinical findings.
0 comments:
Post a Comment